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dc.creatorEleftheriadis, T.en
dc.creatorAntoniadi, G.en
dc.creatorLiakopoulos, V.en
dc.creatorPissas, G.en
dc.creatorArampatzis, S.en
dc.creatorSparopoulou, T.en
dc.creatorGalaktidou, G.en
dc.creatorStefanidis, I.en
dc.date.accessioned2015-11-23T10:26:06Z
dc.date.available2015-11-23T10:26:06Z
dc.date.issued2012
dc.identifier10.1111/j.1744-9987.2012.01080.x
dc.identifier.issn1744-9979
dc.identifier.urihttp://hdl.handle.net/11615/27303
dc.description.abstractPerilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. Thirty-six HD patients and 28 healthy volunteers were enrolled into the study. Ten HD patients suffered from coronary heart disease (CHD). Perilipin-1, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), body mass index, albumin, geriatric nutritional risk index, normalized protein catabolic rate, interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) were measured. Perilipin-1 did not differ between HD patients and healthy volunteers. IL-6 and TNF-a were higher in HD patients. The evaluated nutritional markers and the markers of inflammation did not differ between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels. Regarding the lipid profile, only HDL-C differed between HD patients with high perilipin-1 levels and HD patients with low perilipin-1 levels, and it was higher in the first subgroup. Perilipin-1 was significantly higher in HD patients without CHD. Perilipin-1 is detectable in the serum of HD patients and it is associated with increased HDL-C and decreased incidence of CHD.en
dc.source.uri<Go to ISI>://WOS:000306687300009
dc.subjectCholesterolen
dc.subjectCoronary heart diseaseen
dc.subjectHemodialysisen
dc.subjectInflammationen
dc.subjectNutritionen
dc.subjectPerilipin-1en
dc.subjectTriglyceridesen
dc.subjectATHEROSCLEROSIS MIA SYNDROMEen
dc.subjectNECROSIS-FACTOR-ALPHAen
dc.subjectCHRONIC-RENAL-FAILUREen
dc.subjectCARDIOVASCULAR EVENTSen
dc.subjectDIALYSIS PATIENTSen
dc.subjectLIPOLYSISen
dc.subjectINFLAMMATIONen
dc.subjectCHOLESTEROLen
dc.subjectMETABOLISMen
dc.subjectEXPRESSIONen
dc.subjectHematologyen
dc.subjectUrology & Nephrologyen
dc.titlePerilipin-1 in Hemodialyzed Patients: Association With History of Coronary Heart Disease and Lipid Profileen
dc.typejournalArticleen


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