Retinoid receptor alpha and beta expression in serous ovarian tumors
AuthorDaponte, A.; Kostopoulou, E.; Chiotoglou, I.; Vanakara, P.; Minas, M.; Nakou, M.; Kallitsaris, A.; Kollia, P.; Koukoulis, G.; Messinis, I. E.
The expression of retinoid acid receptors alpha (RAR alpha) and beta (RAR beta) and estrogen receptor alpha (ER alpha) was assessed by immunohistochemistry and Western blotting in normal ovaries, serous cystadenoma (n = 20), serous borderline (n = 14), and serous ovarian cancer (n = 47) and was correlated in cancer cases with stage, grade, progress-free survival (PFS), and survival. RAR alpha was increasingly expressed in benign cystadenomas, borderline, and low-stage and advanced-stage neoplasms (p < 0.001). In stage III, G3 serous carcinoma, increased RAR alpha expression was an independent prognostic factor associated with lower chemoresponse to first-line chemotherapy (taxol and carboplatin) and shorter PFS (p < 0.002). RAR beta and ER alpha expression did not correlate with RAR alpha tumor characteristics or PFS and survival. Copyright (C) 2008 S. Karger AG, Basel.
Showing items related by title, author, creator and subject.
Eleftheriadis, T.; Pissas, G.; Liakopoulos, V.; Stefanidis, I.; Lawson, B. R. (2012)Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. Expressed in immunocytes, TLRs initiate innate immune responses and concurrently shape the subsequent adaptive ...
Blocking of interleukin-10 receptor - A novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus Rigopoulou, E. I.; Abbott, W. G. H.; Haigh, P.; Naoumov, N. V. (2005)Chronic hepatitis C virus (HCV) infection is associated with weak CD4+ T-helper type 1 reactivity and enhanced interleukin-10 production to HCV antigens. Here we demonstrate in vitro that monoclonal antibody-induced blockade ...
Smilevska, T.; Stamatopoulos, K.; Samara, M.; Belessi, C.; Tsompanakou, A.; Paterakis, G.; Stavroyianni, N.; Athanasiadou, I.; Chiotoglou, I.; Hadzidimitriou, A.; Athanasiadou, A.; Douka, V.; Saloum, R.; Laoutaris, N.; Anagnostopoulos, A.; Fassas, A.; Stathakis, N.; Kollia, P. (2006)Transferrin receptor (TfR)-1 and 2 mRNA and CD71 (TfR1) expression was analyzed in 118 CLL patients. Ninety-five out of 109 analyzed cases expressed CD71, mostly at a high level; 60% of CD71 (+) cases were IGH-mutated. All ...