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dc.creatorDailiana, Z. H.en
dc.creatorMalizos, K. N.en
dc.creatorVaritimidis, S.en
dc.creatorHantes, M.en
dc.creatorBasdekis, G.en
dc.creatorRigopoulos, N.en
dc.date.accessioned2015-11-23T10:24:59Z
dc.date.available2015-11-23T10:24:59Z
dc.date.issued2007
dc.identifier10.1097/01.ta.0000233909.88264.43
dc.identifier.issn225282
dc.identifier.urihttp://hdl.handle.net/11615/26818
dc.description.abstractBACKGROUND: Heparin induced thrombosis (HIT) after low-molecular-weight (LMWH) administration for thrombosis prevention is a limb and life threatening condition. METHODS: Two previously healthy individuals, with nonviable forearm amputation and knee osteoarthritis, suffered from multiple arterial thromboses (>2 sites each) after postoperative administration of LMWH. RESULTS: Both patients suffered from thrombocytopenia on the first postoperative days (4-7) and had signs of arterial occlusions on the 9th and 10th postoperative days. The patient with the initially successful forearm replantation was finally amputated below the elbow, whereas the lower extremity of the patient with total knee arthroplasty and contralateral femoral artery occlusion was salvaged with foot fingers amputation only. CONCLUSIONS: Early recognition of the syndrome by monitoring daily platelet counts during heparin therapy is essential. In case of postheparin (LMWH or unfractionated) platelet decrease, heparin administration should be ceased after emergency testing for heparin induced antibodies. When HIT syndrome is confirmed to have occurred, heparin/LMWH must be replaced with thrombin-specific inhibitors. © 2007 Lippincott Williams & Wilkins, Inc.en
dc.sourceJournal of Trauma - Injury, Infection and Critical Careen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-36048930093&partnerID=40&md5=71f0fab0a47ccab152a2721b3c9d3af3
dc.subjectHeparin-induced thrombocytopenia/thrombosisen
dc.subjectLMWHen
dc.subjectOrthopedicsen
dc.subjectTraumaen
dc.subjectWhiteclot syndromeen
dc.subjectheparinen
dc.subjectlow molecular weight heparinen
dc.subjectthrombin inhibitoren
dc.subjectadulten
dc.subjectageden
dc.subjectarm amputationen
dc.subjectartery occlusionen
dc.subjectartery thrombosisen
dc.subjectarticleen
dc.subjectcase reporten
dc.subjectfemaleen
dc.subjectfemoral arteryen
dc.subjectfinger amputationen
dc.subjectforearmen
dc.subjectheparin induced thrombosisen
dc.subjecthumanen
dc.subjectknee osteoarthritisen
dc.subjectmaleen
dc.subjectpatient monitoringen
dc.subjectpostoperative perioden
dc.subjectpriority journalen
dc.subjectreimplantationen
dc.subjectthrombocyte counten
dc.subjectthrombocytopeniaen
dc.subjectthrombosisen
dc.subjecttotal knee replacementen
dc.subjectAmputationen
dc.subjectArthroplasty, Replacement, Kneeen
dc.subjectFollow-Up Studiesen
dc.subjectHeparin, Low-Molecular-Weighten
dc.subjectHumansen
dc.subjectIliac Arteryen
dc.subjectMiddle Ageden
dc.subjectPlatelet Counten
dc.subjectPostoperative Complicationsen
dc.subjectRisk Assessmenten
dc.subjectThrombectomyen
dc.subjectThromboembolismen
dc.subjectTreatment Outcomeen
dc.subjectUpper Extremityen
dc.titleLow-molecular-weight heparin for prevention of thrombosis: Inverted roleen
dc.typejournalArticleen


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