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dc.creatorBogdanos, D. P.en
dc.creatorLenzi, M.en
dc.creatorOkamoto, M.en
dc.creatorRigopoulou, E. I.en
dc.creatorMuratori, P.en
dc.creatorMa, Y.en
dc.creatorMuratori, L.en
dc.creatorTsantoulas, D.en
dc.creatorMieli-Vergani, G.en
dc.creatorBianchi, F. B.en
dc.creatorVergani, D.en
dc.date.accessioned2015-11-23T10:23:56Z
dc.date.available2015-11-23T10:23:56Z
dc.date.issued2004
dc.identifier.issn3946320
dc.identifier.urihttp://hdl.handle.net/11615/26328
dc.description.abstractLiver Kidney Microsomal autoantibody type 1(LKM1) directed to cytochrome P4502D6 (CYP2D6) characterises autoimmune hepatitis type-2 (AIH-2), but is also found in a proportion of chronic hepatitis C virus (HCV) infected patients, CYP2D6252-271 being a major B- cell autoepitope. Molecular mimicry and immunological cross-reactivity between CYP2D6252-271, HCV polyprotein and the infected cell protein 4 (ICP4) of herpes simplex virus type 1 (HSV-1) have been suggested as triggers for the induction of LKM1, but reactivity and cross-reactivity to the relevant sequences have not been investigated experimentally. CYP2D6252-271 and its viral homologues were constructed and tested by ELISA in the sera of 46 chronically infected HCV patients, 23 of whom were LKM1 positive. Reactivity to the E1 HCV and ICP4 HSV1 mimics was frequently found in HCV infected patients irrespectively of their LKM1 status; viral/self cross-reactivity (as indicated by inhibition studies), however, was present in the only 2 of the 23 LKM1 seropositive HCV patients, who possessed the HLA allotype B51. Our results indicate that in HCV infected patients virus/self cross-reactivity is dependent on a specific immunogenetic background, a finding awaiting confirmation by studies in larger series of patients.en
dc.sourceInternational Journal of Immunopathology and Pharmacologyen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-5444251837&partnerID=40&md5=62c53fe37aaf44fe9516b2e60da200a0
dc.subjectHepatitis C virusen
dc.subjectHLA B51en
dc.subjectImmunological cross-reactivityen
dc.subjectautoantibodyen
dc.subjectB lymphocyte antigenen
dc.subjectcell proteinen
dc.subjectcytochrome P450 2D6en
dc.subjectcytochrome P450 2D6[252-271]en
dc.subjectepitopeen
dc.subjectHLA B51 antigenen
dc.subjectinfected cell protein 4en
dc.subjectliver kidney microsome antibodyen
dc.subjectliver kidney microsome autoantibody type 1en
dc.subjectmicrosome antibodyen
dc.subjectpolyproteinen
dc.subjectunclassified drugen
dc.subjectvirus proteinen
dc.subjectanti liver kidney microsome antibodyen
dc.subjectanti-liver kidney microsome antibodyen
dc.subjecthepatitis C antibodyen
dc.subjectHLA B antigenen
dc.subjectHLA Bw51en
dc.subjectHLA-Bw51en
dc.subjectpeptide fragmenten
dc.subjectadulten
dc.subjectageden
dc.subjectallotypeen
dc.subjectamino acid sequenceen
dc.subjectantibody productionen
dc.subjectantigen bindingen
dc.subjectarticleen
dc.subjectautoimmune hepatitisen
dc.subjectautoimmune hepatitis type 2en
dc.subjectautoimmunityen
dc.subjectclinical articleen
dc.subjectcontrolled studyen
dc.subjectcross reactionen
dc.subjectenzyme linked immunosorbent assayen
dc.subjectfemaleen
dc.subjecthepatitis Cen
dc.subjectHerpes simplex virus 1en
dc.subjectHLA typingen
dc.subjecthumanen
dc.subjectimmunogeneticsen
dc.subjectimmunoreactivityen
dc.subjectinhibition kineticsen
dc.subjectkidney microsomeen
dc.subjectliver microsomeen
dc.subjectmaleen
dc.subjectmolecular mimicryen
dc.subjectpriority journalen
dc.subjectserologyen
dc.subjectvirus cross reactionen
dc.subjectvirus immunityen
dc.subjectantibody combining siteen
dc.subjectblooden
dc.subjectgeneticsen
dc.subjectgenotypeen
dc.subjecthistocompatibility testen
dc.subjectimmunologyen
dc.subjectkidneyen
dc.subjectmetabolismen
dc.subjectmiddle ageden
dc.subjectmolecular geneticsen
dc.subjectAutoantibodiesen
dc.subjectBinding Sites, Antibodyen
dc.subjectCross Reactionsen
dc.subjectCytochrome P-450 CYP2D6en
dc.subjectHepacivirusen
dc.subjectHepatitis C Antibodiesen
dc.subjectHepatitis C, Chronicen
dc.subjectHistocompatibility Testingen
dc.subjectHLA-B Antigensen
dc.subjectHumansen
dc.subjectMicrosomes, Liveren
dc.subjectMolecular Sequence Dataen
dc.subjectPeptide Fragmentsen
dc.titleMultiple viral/self immunological cross-reactivity in liver kidney microsomal antibody positive hepatitis C virus-infected patients is associated with the possession of HLA B51en
dc.typejournalArticleen


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