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dc.creatorApostolou, P.en
dc.creatorToloudi, M.en
dc.creatorChatziioannou, M.en
dc.creatorIoannou, E.en
dc.creatorKnocke, D. R.en
dc.creatorNester, J.en
dc.creatorKomiotis, D.en
dc.creatorPapasotiriou, I.en
dc.date.accessioned2015-11-23T10:22:41Z
dc.date.available2015-11-23T10:22:41Z
dc.date.issued2013
dc.identifier10.1186/2050-6511-14-18
dc.identifier.issn1471-2210
dc.identifier.urihttp://hdl.handle.net/11615/25732
dc.description.abstractBackground: Platinum derivatives are used widely for the treatment of many cancers. However, the toxicity that is observed makes imperative the need for new drugs, or new combinations. Anvirzel (TM) is an extract which has been demonstrated with experimental data that displays anticancer activity. The aim of the present study is to determine whether the combination of Cisplatin and Anvirzel (TM) has a synergistic effect against different types of cancer. Materials and methods: To measure the efficacy of treatment with Cisplatin and Anvirzel (TM), methyl-tetrazolium dye (MTT) chemosensitivity assays were used incorporating established human cancer cell lines. Measurements were performed in triplicates, three times, using different incubation times and different concentrations of the two formulations in combination or on their own. t-test was used for statistical analysis. Results: In the majority of the cell lines tested, lower concentrations of Anvirzel (TM) induced a synergistic effect when combined with low concentrations of Cisplatin after an incubation period of 48 to 72 h. The combination of Anvirzel (TM)/Cisplatin showed anti-proliferative effects against a wide range of tumours. Conclusion: The results showed that the combination of Anvirzel (TM) and Cisplatin is more effective than monotherapy, even when administered at low concentrations; thus, undesirable toxic effects can be avoided.en
dc.sourceBmc Pharmacology & Toxicologyen
dc.source.uri<Go to ISI>://WOS:000319699100001
dc.subjectAnvirzel (TM)en
dc.subjectCisplatinen
dc.subjectViability assaysen
dc.subjectCancer cell linesen
dc.subjectMethyl-tetrazolium dyeen
dc.subjectOLEANDRIN SUPPRESSES ACTIVATIONen
dc.subjectFACTOR-KAPPA-Ben
dc.subjectCARDIAC-GLYCOSIDESen
dc.subjectAPOPTOSISen
dc.subjectASSAYen
dc.subjectMTTen
dc.subjectGROWTHen
dc.subjectDEATHen
dc.subjectCHEMOSENSITIVITYen
dc.subjectRESISTANCEen
dc.subjectPharmacology & Pharmacyen
dc.subjectToxicologyen
dc.titleAnvirzel (TM) in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell linesen
dc.typejournalArticleen


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