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Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes

Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Golfinopoulos, S.; Liakopoulos, V.; Mamara, A. M.; Speletas, M.; Koukoulis, G.; Stefanidis, I. (2013)

Background: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1β (IL-1β). Purinergic receptor P2X7 ...