Now showing items 1-13 of 13

  • The 5′ regulatory region of the human fetal globin genes is a gene conversion hotspot 

    Kalamaras, A.; Chassanidis, C.; Samara, M.; Chiotoglou, I.; Vamvakopoulos, N. K.; Papadakis, M. N.; Kollia, P.; Patrinos, G. P. (2008)
    The human fetal globin genes consist of the first mammalian genomic loci for which gene conversion was reported. To date, 14 gene conversions have been described in the human Gγ- and Aγ-globin genes, the vast majority of ...
  • Cell migration leads to spatially distinct but clonally related airway cancer precursors 

    Pipinikas, C. P.; Kiropoulos, T. S.; Teixeira, V. H.; Brown, J. M.; Varanou, A.; Falzon, M.; Capitanio, A.; Bottoms, S. E.; Carrol, B.; Navani, N.; McCaughan, F.; George, J. P.; Giangreco, A.; Wright, N. A.; McDonald, S. A. C.; Graham, T. A.; Janes, S. M. (2014)
    Background Squamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing ...
  • Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine 

    Dedepsidis, E.; Karakasiliotis, I.; Paximadi, E.; Kyriakopoulou, Z.; Komiotis, D.; Markoulatos, P. (2006)
    In the present study, a genomic analysis of full VP1 sequence region of 15 clinical re-isolates (14 healthy vaccinees and one bone marrow tumor patient) was conducted, aiming to the identification of mutations and to the ...
  • Evolution of 2B and 2C genomic parts of species B Coxsackie viruses. Phylogenetic study and comparison with other regions 

    Bolanaki, E.; Kottaridi, C.; Markoulatos, P.; Margaritis, L.; Katsorchis, T. (2006)
    Modern molecular approaches on the genome of enteroviruses' circulating strains have established new data about the mechanism and significance of its evolution. In the present study, 46 enteroviruses isolates, belonging ...
  • Immunoglobulin genes in multiple myeloma: Expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases 

    Hadzidimitriou, A.; Stamatopoulos, K.; Belessi, C.; Lalayianni, C.; Stavroyianni, N.; Smilevska, T.; Hatzi, K.; Laoutaris, N.; Anagnostopoulos, A.; Kollia, P.; Fassas, A. (2006)
    Background and Objectives. The available data on the immunoglobulin gene (IG) repertoire in multiple myeloma (MM) derive mainly from heavy chains; considerably less is known about light chains. We assessed in parallel IGH ...
  • Lincomycin resistance gene lnu(D) in Streptococcus uberis 

    Petinaki, E.; Guérin-Faublée, V.; Pichereau, V.; Villers, C.; Achard, A.; Malbruny, B.; Leclercq, R. (2008)
    Streptococcus uberis UCN 42, isolated from a case of bovine mastitis, was intermediately resistant to lincomycin (MIC = 2 μg/ml) while remaining susceptible to clindamycin (MIC = 0.06 μg/ml) and erythromycin. A 1.1-kb SacI ...
  • Molecular typing of Brucella melitensis endemic strains and differentiation from the vaccine strain Rev-1 

    Noutsios, G. T.; Papi, R. M.; Ekateriniadou, L. V.; Minas, A.; Kyriakidis, D. A. (2012)
    In the present study forty-four Greek endemic strains of Br. melitensis and three reference strains were genotyped by Multi locus Variable Number Tandem Repeat (ML-VNTR) analysis based on an eight-base pair tandem repeat ...
  • Mutations conferring colistin resistance development in Acinetobacter baumannii clinical isolates 

    Dafopoulou, K.; Poulou, A.; Makris, D.; Hadjichristodoulou, C.; Tsakris, A.; Pournaras, S. (2013)
    The colistin resistance mechanisms in Acinetobacter baumannii are largely unknown. In the present study, we investigated the characteristics and the mechanisms of colistin resistance in two genetically indistinguishable ...
  • Novel molecular techniques for the identification of the members of Brucellaceae family 

    Papaventsis, D.; Siafakas, N.; Markoulatos, P.; Sopidou, V.; Economou, C.; Levidiotou-Stefanou, S. (2006)
    An account is presented of an attempt to identify a multiresistant, gram-negative bacterium that was isolated from raw sewage in Cyprus. The API 2ONE system was initially used to identify the strain on the basis of its ...
  • Partial 3D gene sequences of Coxsackie viruses reveal interspecies exchanges 

    Bolanaki, E.; Kottaridi, C.; Markoulatos, P.; Kyriakopoulou, Z.; Margaritis, L.; Katsorchis, T. (2007)
    The 3D region of 46 clinical Coxsackievirus strains, primarily belonging to the human enterovirus B species (HEV-B), were analyzed using nucleotide distance matrices and phylogeny software. The conclusions from previously ...
  • Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration 

    Ratnapriya, R.; Zhan, X.; Fariss, R. N.; Branham, K. E.; Zipprer, D.; Chakarova, C. F.; Sergeev, Y. V.; Campos, M. M.; Othman, M.; Friedman, J. S.; Maminishkis, A.; Waseem, N. H.; Brooks, M.; Rajasimha, H. K.; Edwards, A. O.; Lotery, A.; Klein, B. E.; Truitt, B. J.; Li, B.; Schaumberg, D. A.; Morgan, D. J.; Morrison, M. A.; Souied, E.; Tsironi, E. E.; Grassmann, F.; Fishman, G. A.; Silvestri, G.; Scholl, H. P. N.; Kim, I. K.; Ramke, J.; Tuo, J.; Merriam, J. E.; Merriam, J. C.; Park, K. H.; Olson, L. M.; Farrer, L. A.; Johnson, M. P.; Peachey, N. S.; Lathrop, M.; Baron, R. V.; Igo, R. P.; Klein, R.; Hagstrom, S. A.; Kamatani, Y.; Martin, T. M.; Jiang, Y.; Conley, Y.; Sahel, J. A.; Zack, D. J.; Chan, C. C.; Pericak-Vance, M. A.; Jacobson, S. G.; Gorin, M. B.; Klein, M. L.; Allikmets, R.; Iyengar, S. K.; Weber, B. H.; Haines, J. L.; Léveillard, T.; Deangelis, M. M.; Stambolian, D.; Weeks, D. E.; Bhattacharya, S. E.; Chew, E. Y.; Heckenlively, J. R.; Abecasis, G. R.; Swaroop, A. (2014)
    Neurodegenerative diseases affecting the macula constitute amajor cause of incurable vision loss and exhibit considerable clinical and genetic heterogeneity, from early-onset monogenic disease to multifactorial lateonset ...
  • A short survey on genetic sequences, chou's pseudo amino acid composition and its combination with fuzzy set theory 

    Georgiou, D. N.; Karakasidis, T. E.; Megaritis, A. C. (2013)
    The study of genetic sequences is of great importance in biology and medicine. Sequence analysis and taxonomy are two major fields of application of bioinformatics. In this survey, we present results concerning genetic ...
  • Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia 

    Smilevska, T.; Stamatopoulos, K.; Samara, M.; Belessi, C.; Tsompanakou, A.; Paterakis, G.; Stavroyianni, N.; Athanasiadou, I.; Chiotoglou, I.; Hadzidimitriou, A.; Athanasiadou, A.; Douka, V.; Saloum, R.; Laoutaris, N.; Anagnostopoulos, A.; Fassas, A.; Stathakis, N.; Kollia, P. (2006)
    Transferrin receptor (TfR)-1 and 2 mRNA and CD71 (TfR1) expression was analyzed in 118 CLL patients. Ninety-five out of 109 analyzed cases expressed CD71, mostly at a high level; 60% of CD71 (+) cases were IGH-mutated. All ...