Now showing items 1-15 of 15

  • Angiogenesis and apoptosis-related protein (p53, bcl-2, and bax) expression versus response of gastric adenocarcinomas to paclitaxel and carboplatin chemotherapy 

    Giatromanolaki, A.; Stathopoulos, G. P.; Koukourakis, M. I.; Rigatos, S.; Vrettou, E.; Kittas, C.; Fountzilas, G.; Sivridis, E. (2001)
    The role of angiogenesis and apoptosis-related proteins in defining response to chemotherapy is poorly understood. We examined the microvessel density (MVD) and the expression of p53, bcl-2, and bax proteins in a series ...
  • Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer 

    Giatromanolaki, A.; Koukourakis, M. I.; Stathopoulos, G. P.; Kapsoritakis, A.; Paspatis, G.; Kakolyris, S.; Sivridis, E.; Georgoulias, V.; Harris, A. L.; Gatter, K. C. (2000)
    The assessment of the angiogenic profile of tumors may become an important tool as a guide for the inclusion of novel drugs and molecular therapies into the standard chemoradiotherapy policy. Several studies have shown the ...
  • The angiogenic pathway 'vascular endothelial growth factor/flk-I (KDR)-receptor' in rheumatoid arthritis and osteoarthritis 

    Giatromanolaki, A.; Sivridis, E.; Atanassou, N.; Zois, E.; Thorpe, P. E.; Brekken, R. A.; Gatter, K. C.; Harris, A. L.; Koukourakis, I. M.; Koukourakis, M. I. (2001)
    Active angiogenesis, together with an up-regulation of angiogenic factors, is evident in the synovium of both rheumatoid arthritis (RA) and osteoarthritis (OA). The present study assessed, by immunohistochemistry, the ...
  • Association of Syndecan-1 with Angiogenesis-related Markers, Extracellular Matrix Components, and Clinicopathological Features in Colorectal Carcinoma 

    Mitselou, A.; Skoufi, U.; Tsimogiannis, K. E.; Briasoulis, E.; Vougiouklakis, T.; Arvanitis, D.; Ioachim, E. (2012)
    Syndecan-1 is a transmembrane heparansulfate proteoglycan, which regulates cell proliferation, migration, angiogenesis, cell-to-cell and cell-to-extracellular matrix adhesion and may influence malignant cell behavior. We ...
  • Cancer vascularization: Implications in radiotherapy? 

    Koukourakis, M. I.; Giatromanolaki, A.; Sivridis, E.; Fezoulidis, I. (2000)
    Purpose: Although hypoxia is considered a major cause of failure of radiotherapy, the mechanisms of tumor hypoxia are unclear, and effective ways for its correction or targeting are missing. Tumoral vasculature is the ...
  • Coagulation, angiogenesis, and venous thromboembolism in cancer [10] 

    Agorogiannis, E. I.; Agorogiannis, G. I. (2002)
  • Cognitive function and exercise training for chronic renal disease patients: A literature review 

    Kaltsatou, A.; Grigoriou, S. S.; Karatzaferi, C.; Giannaki, C. D.; Stefanidis, I.; Sakkas, G. K. (2015)
    Objective: Cognitive impairment is very often noted in patients with Chronic Kidney Disease (CKD). Even though, exercise is considered to be a quantifiable activity that improves cognition in animals and humans, it seems ...
  • Endometrial carcinoma: association of steroid hormone receptor expression with low angiogenesis and bcl-2 expression 

    Sivridis, E.; Giatromanolaki, A.; Koukourakis, M.; Anastasiadis, P. (2001)
    In endometrial tissues, malignant change may be accompanied by a loss of hormone dependence which is, usually, reflected in a parallel loss of oestrogen and progesterone receptors (ER and PR). In this study, the steroid ...
  • Expression of heregulin in human coronary atherosclerotic lesions 

    Panutsopulos, D.; Arvanitis, D. L.; Tsatsanis, C.; Papalambros, E.; Sigala, F.; Spandidos, D. A. (2005)
    Background: Endothelial cells, monocytes/macrophages, and vascular smooth muscle cells contribute to the establishment and progression of atherosclerotic lesions by expressing growth and inflammatory factors. The aim of ...
  • FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic FLT1 Expression 

    Owen, L. A.; Morrison, M. A.; Ahn, J.; Woo, S. J.; Sato, H.; Robinson, R.; Morgan, D. J.; Zacharaki, F.; Simeonova, M.; Uehara, H.; Chakravarthy, U.; Hogg, R. E.; Ambati, B. K.; Kotoula, M.; Baehr, W.; Haider, N. B.; Silvestri, G.; Miller, J. W.; Tsironi, E. E.; Farrer, L. A.; Kim, I. K.; Park, K. H.; DeAngelis, M. M. (2014)
    PURPOSE. Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of ...
  • HIF-1a in colorectal carcinoma: review of the literature 

    Ioannou, M.; Paraskeva, E.; Baxevanidou, K.; Simos, G.; Papamichali, R.; Papacharalambous, C.; Samara, M.; Koukoulis, G. (2015)
    Colorectal cancer (CRC) is the third most common cancer worldwide and despite the abundance of molecular pathways and markers continually being reported, the mortality rates remain high. Hypoxia inducible factor 1alpha ...
  • Novel conformationally constrained pyrazole derivatives as potential anti-cancer agents 

    Kasiotis, K. M.; Tzanetou, E. N.; Stagos, D.; Fokialakis, N.; Koutsotheodorou, E.; Kouretas, D.; Haroutounian, S. A. (2015)
    The synthesis of 17 novel conformationally constrained pyrazole derivatives is reported herein, along with the assessment of their anti-proliferative and anti-angiogenic activities. The evaluation of their inhibitory effect ...
  • Prognostic role of angiogenesis in operable carcinoma of the gallbladder 

    Giatromanolaki, A.; Sivridis, E.; Koukourakis, M. I.; Polychronidis, A.; Simopoulos, C. (2002)
    The prognostic significance of intratumoral angiogenesis was investigated in 62 patients with stage I-III carcinomas of the gallbladder treated with simple cholecystectomy. Microvessel density (MVD) was assessed ...
  • Seven new loci associated with age-related macular degeneration 

    Fritsche, L. G.; Chen, W.; Schu, M.; Yaspan, B. L.; Yu, Y.; Thorleifsson, G.; Zack, D. J.; Arakawa, S.; Cipriani, V.; Ripke, S.; Igo, R. P.; Buitendijk, G. H. S.; Sim, X.; Weeks, D. E.; Guymer, R. H.; Merriam, J. E.; Francis, P. J.; Hannum, G.; Agarwal, A.; Armbrecht, A. M.; Audo, I.; Aung, T.; Barile, G. R.; Benchaboune, M.; Bird, A. C.; Bishop, P. N.; Branham, K. E.; Brooks, M.; Brucker, A. J.; Cade, W. H.; Cain, M. S.; Campochiaro, P. A.; Chan, C. C.; Cheng, C. Y.; Chew, E. Y.; Chin, K. A.; Chowers, I.; Clayton, D. G.; Cojocaru, R.; Conley, Y. P.; Cornes, B. K.; Daly, M. J.; Dhillon, B.; Edwards, A. O.; Evangelou, E.; Fagerness, J.; Ferreyra, H. A.; Friedman, J. S.; Geirsdottir, A.; George, R. J.; Gieger, C.; Gupta, N.; Hagstrom, S. A.; Harding, S. P.; Haritoglou, C.; Heckenlively, J. R.; Holz, F. G.; Hughes, G.; Ioannidis, J. P. A.; Ishibashi, T.; Joseph, P.; Jun, G.; Kamatani, Y.; Katsanis, N.; N Keilhauer, C.; Khan, J. C.; Kim, I. K.; Kiyohara, Y.; Klein, B. E. K.; Klein, R.; Kovach, J. L.; Kozak, I.; Lee, C. J.; Lee, K. E.; Lichtner, P.; Lotery, A. J.; Meitinger, T.; Mitchell, P.; Mohand-Saïd, S.; Moore, A. T.; Morgan, D. J.; Morrison, M. A.; Myers, C. E.; Naj, A. C.; Nakamura, Y.; Okada, Y.; Orlin, A.; Ortube, M. C.; Othman, M. I.; Pappas, C.; Park, K. H.; Pauer, G. J. T.; Peachey, N. S.; Poch, O.; Priya, R. R.; Reynolds, R.; Richardson, A. J.; Ripp, R.; Rudolph, G.; Ryu, E.; Sahel, J. A.; Schaumberg, D. A.; Scholl, H. P. N.; Schwartz, S. G.; Scott, W. K.; Shahid, H.; Sigurdsson, H.; Silvestri, G.; Sivakumaran, T. A.; Smith, R. T.; Sobrin, L.; Souied, E. H.; Stambolian, D. E.; Stefansson, H.; Sturgill-Short, G. M.; Takahashi, A.; Tosakulwong, N.; Truitt, B. J.; Tsironi, E. E.; Uitterlinden, A. G.; Van Duijn, C. M.; Vijaya, L.; Vingerling, J. R.; Vithana, E. N.; Webster, A. R.; Wichmann, H. E.; Winkler, T. W.; Wong, T. Y.; Wright, A. F.; Zelenika, D.; Zhang, M.; Zhao, L.; Zhang, K.; Klein, M. L.; Hageman, G. S.; Lathrop, G. M.; Stefansson, K.; Allikmets, R.; Baird, P. N.; Gorin, M. B.; Wang, J. J.; Klaver, C. C. W.; Seddon, J. M.; Pericak-Vance, M. A.; Iyengar, S. K.; Yates, J. R. W.; Swaroop, A.; Weber, B. H. F.; Kubo, M.; Deangelis, M. M.; Léveillard, T.; Thorsteinsdottir, U.; Haines, J. L.; Farrer, L. A.; Heid, I. M.; Abecasis, G. R. (2013)
    Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association ...
  • Thymidine phosphorylase expression in normal and hyperplastic endometrium 

    Sivridis, E.; Giatromanolaki, A.; Koukourakis I, M.; Bicknell, R.; Harris, A. L.; Gatter, K. C. (2000)
    Aims - To investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in normally cycling endometrium and various forms of endometrial hyperplasia. Methods - TP expression ...