Now showing items 1-4 of 4

  • Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies 

    Rodriguez-Fontenla, C.; Calaza, M.; Evangelou, E.; Valdes, A. M.; Arden, N.; Blanco, F. J.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; Esko, T.; Aleta, C. M. G.; Carnota, Jjgr; Helgadottir, H.; Hofman, A.; Jonsdottir, I.; Kerkhof, H. J. M.; Kloppenburg, M.; McCaskie, A.; Ntzani, E. E.; Ollier, W. E. R.; Oreiro, N.; Panoutsopoulou, K.; Ralston, S. H.; Ramos, Y. F.; Riancho, J. A.; Rivadeneira, F.; Slagboom, P. E.; Styrkarsdottir, U.; Thorsteinsdottir, U.; Thorleifsson, G.; Tsezou, A.; Uitterlinden, A. G.; Wallis, G. A.; Wilkinson, J. M.; Zhai, G. J.; Zhu, Y. Y.; Felson, D. T.; Ioannidis, J. P. A.; Loughlin, J.; Metspalu, A.; Meulenbelt, I.; Stefansson, K.; van Meurs, J. B.; Zeggini, E.; Spector, T. D.; Gonzalez, A.; arc, Ogen Consortium (2014)
    Objective. To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods. A total of 199 candidate genes ...
  • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study 

    Panoutsopoulou, K.; Southam, L.; Elliott, K. S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N. K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W. E. R.; Ralston, S. H.; Spector, T. D.; Valdes, A. M.; Wallis, G. A.; Wilkinson, J. M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F. J.; Bumpstead, S.; Cupples, L. A.; Day-Williams, A. G.; Dixon, K.; Doherty, S. A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J. J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hunt, S. E.; Ioannidis, J. P. A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H. J. M.; Kloppenburg, M. G.; Koller, N.; Lakenberg, N.; Lane, N. E.; Lee, A. T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M. C.; O'Neill, F.; Parimi, N.; Potter, S. C.; Rego-Perez, I.; Riancho, J. A.; Sherburn, K.; Slagboom, P. E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A. G.; van Meurs, J. B. J.; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J. M.; Zeggini, E.; Loughlin, J.; arc, Ogen Consortium (2011)
    Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...
  • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

    Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
    Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...
  • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 

    Evangelou, E.; Valdes, A. M.; Kerkhof, H. J. M.; Styrkarsdottir, U.; Zhu, Y.; Meulenbelt, I.; Lories, R. J.; Karassa, F. B.; Tylzanowski, P.; Bos, S. D.; Rayner, N. W.; Southam, L.; Zhai, G.; Elliott, K. S.; Hunt, S. E.; Blackburn, H.; Potter, S. C.; Day-Williams, A. G.; Beazley, C.; Akune, T.; Arden, N. K.; Carr, A.; Chapman, K.; Cupples, L. A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B. V.; Hammond, C. L.; Hart, D. J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U. M.; Lohmander, L. S.; Loughlin, J.; Luyten, F. P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P. M.; Nishida, N.; Ollier, W. E. R.; Panoutsopoulou, K.; Van De Putte, T.; Ralston, S. H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.; Slagboom, P. E.; Sudo, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G. A.; Wilkinson, J. M.; Yoshimura, N.; Zeggini, E.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A. G.; Felson, D. T.; Van Meurs, J. B.; Stefansson, K.; Ioannidis, J. P. A.; Spector, T. D. (2011)
    Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including ...