Now showing items 1-14 of 14

  • Ancestry of the Timorese: Age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world 

    Morrison, M. A.; Magalhaes, T. R.; Ramke, J.; Smith, S. E.; Ennis, S.; Simpson, C. L.; Portas, L.; Murgia, F.; Ahn, J.; Dardenne, C.; Mayne, K.; Robinson, R.; Morgan, D. J.; Brian, G.; Lee, L.; Woo, S. J.; Zacharaki, F.; Tsironi, E. E.; Miller, J. W.; Kim, I. K.; Park, K. H.; Bailey-Wilson, J. E.; Farrer, L. A.; Stambolian, D.; DeAngelis, M. M. (2015)
    We observed that the third leading cause of blindness in the world, age-related macular degeneration (AMD), occurs at a very low documented frequency in a population-based cohort from Timor-Leste. Thus, we determined a ...
  • Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: A systems biology based approach 

    Silveira, A. C.; Morrison, M. A.; Ji, F.; Xu, H.; Reinecke, J. B.; Adams, S. M.; Arneberg, T. M.; Janssian, M.; Lee, J. E.; Yuan, Y.; Schaumberg, D. A.; Kotoula, M. G.; Tsironi, E. E.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Miller, J. W.; Kim, I. K.; Hageman, G. S.; Farrer, L. A.; Haider, N. B.; DeAngelis, M. M. (2010)
    To identify novel genes and pathways associated with AMD, we performed microarray gene expression and linkage analysis which implicated the candidate gene, retinoic acid receptor-related orphan receptor alpha (RORA, 15q). ...
  • European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate 

    Tsironi, E. E.; Zacharaki, F.; Grivea, I. N.; Tachmitzi, S. V.; Michoula, A. N.; Vlychou, M.; Petinaki, E.; Syrogiannopoulos, G. A. (2012)
    Background: Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed ...
  • Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma 

    Tsironi, E. E.; Pefkianaki, M.; Tsezou, A.; Kotoula, M. G.; Dardiotis, E.; Almpanidou, P.; Papathanasiou, A. A.; Rodopoulou, P.; Chatzoulis, D. Z.; Hadjigeorgiou, G. M. (2009)
    Purpose: To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. ...
  • FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic FLT1 Expression 

    Owen, L. A.; Morrison, M. A.; Ahn, J.; Woo, S. J.; Sato, H.; Robinson, R.; Morgan, D. J.; Zacharaki, F.; Simeonova, M.; Uehara, H.; Chakravarthy, U.; Hogg, R. E.; Ambati, B. K.; Kotoula, M.; Baehr, W.; Haider, N. B.; Silvestri, G.; Miller, J. W.; Tsironi, E. E.; Farrer, L. A.; Kim, I. K.; Park, K. H.; DeAngelis, M. M. (2014)
    PURPOSE. Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of ...
  • Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology 

    Jun, G.; Nicolaou, M.; Morrison, M. A.; Buros, J.; Morgan, D. J.; Radeke, M. J.; Yonekawa, Y.; Tsironi, E. E.; Kotoula, M. G.; Zacharaki, F.; Mollema, N.; Yuan, Y.; Miller, J. W.; Haider, N. B.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; Farrer, L. A.; DeAngelis, M. M. (2011)
    ROBO1 is a strong candidate gene for age-related macular degeneration (AMD) based upon its location under a linkage peak on chromosome 3p12, its expression pattern, and its purported function in a pathway that includes ...
  • Intravitreal bevacizumab for photodynamic therapy-induced massive macular detachment in acute central serous chorioretinopathy 

    Kotoula, M. G.; Zacharaki, F.; Tsironi, E. E. (2012)
    We present a long followed up case of acute central serous chorioretinopathy (CSC) complicated by a severe visual loss due to massive pigment epithelium detachment of the macula after a full-dose photodynamic therapy (PDT). ...
  • Perimetric and retinal nerve fiber layer findings in patients with Parkinson's disease 

    Tsironi, E. E.; Dastiridou, A.; Katsanos, A.; Dardiotis, E.; Veliki, S.; Patramani, G.; Zacharaki, F.; Ralli, S.; Hadjigeorgiou, G. M. (2012)
    Background: Visual dysfunction is common in Parkinson's disease (PD). It remains, however, unknown whether it is related to structural alterations of the retina. The aim of this study is to compare visual field (VF) findings ...
  • Plasma homocysteine and genetic variants of homocysteine metabolism enzymes in patients from central greece with primary open-angle glaucoma and pseudoexfoliation glaucoma 

    Zacharaki, F.; Hadjigeorgiou, G. M.; Koliakos, G. G.; Morrison, M. A.; Tsezou, A.; Chatzoulis, D. Z.; Almpanidou, P.; Topouridou, K.; Karabatsas, H. C.; Pefkianaki, M.; DeAngelis, M. M.; Tsironi, E. E. (2014)
    Background: The purpose of this study was to investigate plasma homocysteine levels and polymorphisms in genes encoding enzymes in the metabolic pathway of homocysteine in association with primary open-angle glaucoma (POAG) ...
  • Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration 

    Ratnapriya, R.; Zhan, X.; Fariss, R. N.; Branham, K. E.; Zipprer, D.; Chakarova, C. F.; Sergeev, Y. V.; Campos, M. M.; Othman, M.; Friedman, J. S.; Maminishkis, A.; Waseem, N. H.; Brooks, M.; Rajasimha, H. K.; Edwards, A. O.; Lotery, A.; Klein, B. E.; Truitt, B. J.; Li, B.; Schaumberg, D. A.; Morgan, D. J.; Morrison, M. A.; Souied, E.; Tsironi, E. E.; Grassmann, F.; Fishman, G. A.; Silvestri, G.; Scholl, H. P. N.; Kim, I. K.; Ramke, J.; Tuo, J.; Merriam, J. E.; Merriam, J. C.; Park, K. H.; Olson, L. M.; Farrer, L. A.; Johnson, M. P.; Peachey, N. S.; Lathrop, M.; Baron, R. V.; Igo, R. P.; Klein, R.; Hagstrom, S. A.; Kamatani, Y.; Martin, T. M.; Jiang, Y.; Conley, Y.; Sahel, J. A.; Zack, D. J.; Chan, C. C.; Pericak-Vance, M. A.; Jacobson, S. G.; Gorin, M. B.; Klein, M. L.; Allikmets, R.; Iyengar, S. K.; Weber, B. H.; Haines, J. L.; Léveillard, T.; Deangelis, M. M.; Stambolian, D.; Weeks, D. E.; Bhattacharya, S. E.; Chew, E. Y.; Heckenlively, J. R.; Abecasis, G. R.; Swaroop, A. (2014)
    Neurodegenerative diseases affecting the macula constitute amajor cause of incurable vision loss and exhibit considerable clinical and genetic heterogeneity, from early-onset monogenic disease to multifactorial lateonset ...
  • Resolution of Macular Edema in Idiopathic Juxtafoveal Telangiectasis Using PDT 

    Kotoula, M. G.; Chatzoulis, D. Z.; Karabatsas, C. H.; Tsiloulis, A.; Tsironi, E. E. (2009)
    A 57-year-old woman was treated by, photodynamic therapy for macular edema due to idiopathic juxtafoveal telangiectasis (presumed type 1A) without subretinal neovascularization. Initial visual acuity of the treated eye was ...
  • Seven new loci associated with age-related macular degeneration 

    Fritsche, L. G.; Chen, W.; Schu, M.; Yaspan, B. L.; Yu, Y.; Thorleifsson, G.; Zack, D. J.; Arakawa, S.; Cipriani, V.; Ripke, S.; Igo, R. P.; Buitendijk, G. H. S.; Sim, X.; Weeks, D. E.; Guymer, R. H.; Merriam, J. E.; Francis, P. J.; Hannum, G.; Agarwal, A.; Armbrecht, A. M.; Audo, I.; Aung, T.; Barile, G. R.; Benchaboune, M.; Bird, A. C.; Bishop, P. N.; Branham, K. E.; Brooks, M.; Brucker, A. J.; Cade, W. H.; Cain, M. S.; Campochiaro, P. A.; Chan, C. C.; Cheng, C. Y.; Chew, E. Y.; Chin, K. A.; Chowers, I.; Clayton, D. G.; Cojocaru, R.; Conley, Y. P.; Cornes, B. K.; Daly, M. J.; Dhillon, B.; Edwards, A. O.; Evangelou, E.; Fagerness, J.; Ferreyra, H. A.; Friedman, J. S.; Geirsdottir, A.; George, R. J.; Gieger, C.; Gupta, N.; Hagstrom, S. A.; Harding, S. P.; Haritoglou, C.; Heckenlively, J. R.; Holz, F. G.; Hughes, G.; Ioannidis, J. P. A.; Ishibashi, T.; Joseph, P.; Jun, G.; Kamatani, Y.; Katsanis, N.; N Keilhauer, C.; Khan, J. C.; Kim, I. K.; Kiyohara, Y.; Klein, B. E. K.; Klein, R.; Kovach, J. L.; Kozak, I.; Lee, C. J.; Lee, K. E.; Lichtner, P.; Lotery, A. J.; Meitinger, T.; Mitchell, P.; Mohand-Saïd, S.; Moore, A. T.; Morgan, D. J.; Morrison, M. A.; Myers, C. E.; Naj, A. C.; Nakamura, Y.; Okada, Y.; Orlin, A.; Ortube, M. C.; Othman, M. I.; Pappas, C.; Park, K. H.; Pauer, G. J. T.; Peachey, N. S.; Poch, O.; Priya, R. R.; Reynolds, R.; Richardson, A. J.; Ripp, R.; Rudolph, G.; Ryu, E.; Sahel, J. A.; Schaumberg, D. A.; Scholl, H. P. N.; Schwartz, S. G.; Scott, W. K.; Shahid, H.; Sigurdsson, H.; Silvestri, G.; Sivakumaran, T. A.; Smith, R. T.; Sobrin, L.; Souied, E. H.; Stambolian, D. E.; Stefansson, H.; Sturgill-Short, G. M.; Takahashi, A.; Tosakulwong, N.; Truitt, B. J.; Tsironi, E. E.; Uitterlinden, A. G.; Van Duijn, C. M.; Vijaya, L.; Vingerling, J. R.; Vithana, E. N.; Webster, A. R.; Wichmann, H. E.; Winkler, T. W.; Wong, T. Y.; Wright, A. F.; Zelenika, D.; Zhang, M.; Zhao, L.; Zhang, K.; Klein, M. L.; Hageman, G. S.; Lathrop, G. M.; Stefansson, K.; Allikmets, R.; Baird, P. N.; Gorin, M. B.; Wang, J. J.; Klaver, C. C. W.; Seddon, J. M.; Pericak-Vance, M. A.; Iyengar, S. K.; Yates, J. R. W.; Swaroop, A.; Weber, B. H. F.; Kubo, M.; Deangelis, M. M.; Léveillard, T.; Thorsteinsdottir, U.; Haines, J. L.; Farrer, L. A.; Heid, I. M.; Abecasis, G. R. (2013)
    Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association ...
  • Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration 

    Morrison, M. A.; Silveira, A. C.; Huynh, N.; Jun, G.; Smith, S. E.; Zacharaki, F.; Sato, H.; Loomis, S.; Andreoli, M. T.; Adams, S. M.; Radeke, M. J.; Jelcick, A. S.; Yuan, Y.; Tsiloulis, A. N.; Chatzoulis, D. Z.; Silvestri, G.; Kotoula, M. G.; Tsironi, E. E.; Hollis, B. W.; Chen, R.; Haider, N. B.; Miller, J. W.; Farrer, L. A.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; DeAngelis, M. M. (2011)
    Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be ...
  • THAP1 mutations in a Greek primary blepharospasm series 

    Xiromerisiou, G.; Dardiotis, E.; Tsironi, E. E.; Hadjigeorgiou, G.; Ralli, S.; Kara, E.; Petalas, A.; Tachmitzi, S.; Hardy, J.; Houlden, H. (2013)