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  • FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic FLT1 Expression 

    Owen, L. A.; Morrison, M. A.; Ahn, J.; Woo, S. J.; Sato, H.; Robinson, R.; Morgan, D. J.; Zacharaki, F.; Simeonova, M.; Uehara, H.; Chakravarthy, U.; Hogg, R. E.; Ambati, B. K.; Kotoula, M.; Baehr, W.; Haider, N. B.; Silvestri, G.; Miller, J. W.; Tsironi, E. E.; Farrer, L. A.; Kim, I. K.; Park, K. H.; DeAngelis, M. M. (2014)
    PURPOSE. Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of ...