Now showing items 1-10 of 10

  • Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes 

    Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)
    Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ...
  • Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism 

    Simopoulou, T.; Malizos, K. N.; Iliopoulos, D.; Stefanou, N.; Papatheodorou, L.; Ioannou, M.; Tsezou, A. (2007)
    Objective: To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA). Methods: Messenger RNA (mRNA) expression and protein levels of leptin and leptin's receptor isoforms were ...
  • Factors affecting the quality of life after total knee arthroplasties: a prospective study 

    Papakostidou, I.; Dailiana, Z. H.; Papapolychroniou, T.; Liaropoulos, L.; Zintzaras, E.; Karachalios, T. S.; Malizos, K. N. (2012)
    Background: The purpose of the study is to evaluate the self-reported outcomes in the first year after primary total knee arthroplasty (TKA), and to determine factors influencing the quality of life (QoL) 6 weeks, 3, 6, ...
  • Lipid metabolism and osteoarthritis: Lessons from atherosclerosis 

    Gkretsi, V.; Simopoulou, T.; Tsezou, A. (2011)
    Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of handicap in the Western world. Interestingly, to date, there are neither available biomarkers for early diagnosis of the disease nor ...
  • Migfilin's elimination from osteoarthritic chondrocytes further promotes the osteoarthritic phenotype via beta-catenin upregulation 

    Gkretsi, V.; Papanikolaou, V.; Dubos, S.; Papathanasiou, I.; Giotopoulou, N.; Valiakou, V.; Wu, C. Y.; Malizos, K. N.; Tsezou, A. (2013)
    Osteoarthritis (OA) is a debilitating disease of the joints characterized by cartilage degradation but to date there is no available pharmacological treatment to inhibit disease progression neither is there any available ...
  • MR imaging findings in early osteoarthritis of the knee 

    Karachalios, T.; Zibis, A.; Papanagiotou, P.; Karantanas, A. H.; Malizos, K. N.; Roidis, N. (2004)
    Purpose: To carry out a modern diagnostic survey among patients with a clinical and radiological diagnosis of early osteoarthritis of the knee. Materials and methods:A magnetic resonance imaging survey was performed on 70 ...
  • No difference in osteoarthritis after surgical and non-surgical treatment of ACL-injured knees after 10 years 

    Tsoukas, D.; Fotopoulos, V.; Basdekis, G.; Makridis, K. G. (2015)
    Purpose: Aim of this study was to record and compare the functional and activity level as well as the manifestations of osteoarthritis after isolated ACL ruptures between patients with conservative treatment and ACL ...
  • Osteoarthritis Year in Review 2014: genetics and genomics 

    Tsezou, A. (2014)
    Recent developments in genetics/genomics of osteoarthritis (OA) are discussed to improve our understanding of OA pathophysiology. The discovery of a novel variant near the NCOA3 (nuclear receptor coactivator 3) gene ...
  • Oxidative stress and inflammatory responses following an acute bout of isokinetic exercise in obese women with knee osteoarthritis 

    Germanou, E. I.; Chatzinikolaou, A.; Malliou, P.; Beneka, A.; Jamurtas, A. Z.; Bikos, C.; Tsoukas, D.; Theodorou, A.; Katrabasas, I.; Margonis, K.; Douroudos, I.; Gioftsidou, A.; Fatouros, I. G. (2013)
    Background: Obesity is associated with osteoarthritis and it is accompanied by chronic inflammation and elevated oxidative stress. Strengthening-type exercise is used in knee osteoarthritis (KOA) rehabilitation. This study ...
  • Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium 

    Kerkhof, H. J. M.; Meulenbelt, I.; Akune, T.; Arden, N. K.; Aromaa, A.; Bierma-Zeinstra, S. M. A.; Carr, A.; Cooper, C.; Dai, J.; Doherty, M.; Doherty, S. A.; Felson, D.; Gonzalez, A.; Gordon, A.; Harilainen, A.; Hart, D. J.; Hauksson, V. B.; Heliovaara, M.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Jonsdottir, I.; Kawaguchi, H.; Kloppenburg, M.; Kujala, U. M.; Lane, N. E.; Leino-Arjas, P.; Lohmander, L. S.; Luyten, F. P.; Malizos, K. N.; Nakajima, M.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Shi, D.; Slagboom, E.; Spector, T. D.; Stefansson, K.; Sudo, A.; Tamm, A.; Tamm, A. E.; Tsezou, A.; Uchida, A.; Uitterlinden, A. G.; Wilkinson, J. M.; Yoshimura, N.; Valdes, A. M.; van Meurs, J. B. J. (2011)
    Objective: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. Methods: Descriptions ...