Now showing items 1-20 of 30

  • THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS 

    Panoutsopoulou, K.; Southam, L.; Rayner, W.; Zhai, G.; Beazley, C.; Arden, N.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Olher, W.; Ralston, S.; Spector, T.; Valdes, A.; Wallis, G.; Wilkinson, M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.; Bumpstead, S.; Cupples, A.; Day-Williams, A.; Dixon, K.; Dohertys, S.; Elliott, K.; Evangelou, E.; Felson, D.; Gomez-Reino, J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Hofman, A.; Hunt, S.; Ioannidis, J.; Jonsdottir, I.; Keen, R.; Kerkhof, H.; Kloppenburg, M.; Koller, N.; Lakenberg, N.; Lane, N.; Lee, A.; Meulenbelt, I.; Nevitt, M.; O'Neill, F.; Parimi, N.; Potter, S.; Rego-Perez, I.; Riancho, J.; Sherburn, K.; Slagboom, E.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Tsezou, A.; Uitterlinden, A.; van Meurs, J.; Watkins, B.; Wheeler, M.; Mitchelle, S.; Zhu, Y.; Zmuda, J.; Zeggini, E.; Loughlin, J.; Arc, Ogen Consortium (2010)
  • Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies 

    Rodriguez-Fontenla, C.; Calaza, M.; Evangelou, E.; Valdes, A. M.; Arden, N.; Blanco, F. J.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; Esko, T.; Aleta, C. M. G.; Carnota, Jjgr; Helgadottir, H.; Hofman, A.; Jonsdottir, I.; Kerkhof, H. J. M.; Kloppenburg, M.; McCaskie, A.; Ntzani, E. E.; Ollier, W. E. R.; Oreiro, N.; Panoutsopoulou, K.; Ralston, S. H.; Ramos, Y. F.; Riancho, J. A.; Rivadeneira, F.; Slagboom, P. E.; Styrkarsdottir, U.; Thorsteinsdottir, U.; Thorleifsson, G.; Tsezou, A.; Uitterlinden, A. G.; Wallis, G. A.; Wilkinson, J. M.; Zhai, G. J.; Zhu, Y. Y.; Felson, D. T.; Ioannidis, J. P. A.; Loughlin, J.; Metspalu, A.; Meulenbelt, I.; Stefansson, K.; van Meurs, J. B.; Zeggini, E.; Spector, T. D.; Gonzalez, A.; arc, Ogen Consortium (2014)
    Objective. To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods. A total of 199 candidate genes ...
  • ASSOCIATION OF A BMP5 MICROSATELLITE WITH KNEE OSTEOARTHRITIS 

    Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)
  • Association of a BMP5 microsatellite with knee osteoarthritis: case-control study 

    Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)
    Introduction: We aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection. Methods: OA patients ...
  • Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes 

    Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)
    Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ...
  • Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis 

    Montes, A.; Perez-Pampin, E.; Narváez, J.; Cañete, J. D.; Navarro-Sarabia, F.; Moreira, V.; Fernández-Nebro, A.; Del Carmen Ordóñez, M.; De La Serna, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Gómez-Reino, J. J.; Gonzalez, A. (2014)
    OBJECTIVES: We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response to Fc-containing inhibitors of tumor necrosis factor (TNF). METHODS: A total of 429 biologic-naive ...
  • Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis 

    Kerkhof, H. J. M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Spector, T. D.; Stolk, L.; Tsezou, A.; Uitterlinden, A. G.; Valdes, A. M.; van Meurs, J. B. J. (2010)
    Background: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis. Methods: In the discovery study, the Rotterdam Study-I, 7 single nucleotide ...
  • DEEP SEQUENCING OF GDF5 IN OVER 1900 OSTEOARTHRITIS CASES AND CONTROLS REVEALS NOVEL AND POTENTIALLY FUNCTIONAL RARE VARIANTS IN THE PROTEIN CODING AND PROMOTER REGIONS OF THE GENE 

    Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Gonzalez, A.; Loughlin, J. (2010)
  • Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus 

    Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Reynard, L. N.; Gonzalez, A.; Loughlin, J. (2011)
    Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ...
  • Erratum to A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis [Bone, 44S2 (2009) S224] 

    Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; van der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; van de Putte, T.; Rivadeneira, F.; Slagboom, E. P.; Styrkársdóttir, U.; Tsezou, A.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; van Meurs, J. B. J. (2010)
  • FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors 

    Montes, A.; Perez-Pampin, E.; Joven, B.; Carreira, P.; Fernandez-Nebro, A.; Ordonez, M. D.; Navarro-Sarabia, F.; Moreira, V.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Canete, J. D.; de la Serna, A. R.; Magallares, B.; Narvaez, J.; Gomez-Reino, J. J.; Gonzalez, A. (2015)
    Objectives: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other Fc gamma R functional polymorphisms. ...
  • Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis 

    Rodriguez-Lopez, J.; Mustafa, Z.; Pombo-Suarez, M.; Malizos, K. N.; Rego, I.; Blanco, F. J.; Tsezou, A.; Loughlin, J.; Gomez-Reino, J. J.; Gonzalez, A. (2008)
    Objective. Given the recent characterization of ADAMTS-5 as the main aggrecanase of cartilage destruction in mouse models, we explored whether genetic variation and, in particular, putative damaging polymorphisms in the ...
  • A genome-wide association study identifies a common variant near the GRP22 gene as a new locus involved in prevalence and progression of osteoarthritis 

    Kerkhof, H. J. M.; Jonsdottir, I.; Meulenbelt, I.; Stolk, L.; Valdes, A. M.; Zhai, G.; Zhu, Y.; Doherty, M.; Doherty, S.; Tsezou, A.; Gonzalez, A.; Carr, A.; Felson, D. T.; Styrkarsdottir, U.; Slagboom, E. P.; Loughlin, J.; Rivadeneira, F.; Hofman, A.; Pols, H. A. P.; Spector, T. D.; Uitterlinden, A. G.; van Meurs, J. B. J. (2009)
  • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 

    Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; Van Der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Styrḱarsd́ottir, U.; Tsezou, A.; Van De Putte, T.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; Van Meurs, J. B. J. (2010)
    Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 ...
  • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study 

    Panoutsopoulou, K.; Southam, L.; Elliott, K. S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N. K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W. E. R.; Ralston, S. H.; Spector, T. D.; Valdes, A. M.; Wallis, G. A.; Wilkinson, J. M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F. J.; Bumpstead, S.; Cupples, L. A.; Day-Williams, A. G.; Dixon, K.; Doherty, S. A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J. J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hunt, S. E.; Ioannidis, J. P. A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H. J. M.; Kloppenburg, M. G.; Koller, N.; Lakenberg, N.; Lane, N. E.; Lee, A. T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M. C.; O'Neill, F.; Parimi, N.; Potter, S. C.; Rego-Perez, I.; Riancho, J. A.; Sherburn, K.; Slagboom, P. E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A. G.; van Meurs, J. B. J.; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J. M.; Zeggini, E.; Loughlin, J.; arc, Ogen Consortium (2011)
    Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...
  • Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis 

    Marquez, A.; Ferreiro-Iglesias, A.; Davila-Fajardo, C. L.; Montes, A.; Pascual-Salcedo, D.; Perez-Pampin, E.; Moreno-Ramos, M. J.; Garcia-Portales, R.; Navarro, F.; Moreira, V.; Magro, C.; Caliz, R.; Ferrer, M. A.; Alegre-Sancho, J. J.; Joven, B.; Carreira, P.; Balsa, A.; Vasilopoulos, Y.; Sarafidou, T.; Cabeza-Barrera, J.; Narvaez, J.; Raya, E.; Canete, J. D.; Fernandez-Nebro, A.; Ordonez, M. D.; de la Serna, A. R.; Magallares, B.; Gomez-Reino, J. J.; Gonzalez, A.; Martin, J. (2014)
    Introduction: In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with ...
  • Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations 

    Meulenbelt, I.; Chapman, K.; Dieguez-Gonzalez, R.; Shi, D.; Tsezou, A.; Dai, J.; Malizos, K. N.; Kloppenburg, M.; Carr, A.; Nakajima, M.; van der Breggen, R.; Lakenberg, N.; Gomez-Reino, J. J.; Jiang, Q.; Ikegawa, S.; Gonzalez, A.; Loughlin, J.; Slagboom, E. P. (2009)
    Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently ...
  • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

    Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
    Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...
  • Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility 

    Meulenbelt, I.; Bos, S. D.; Chapman, K.; van der Breggen, R.; Houwing-Duistermaat, J. J.; Kremer, D.; Kloppenburg, M.; Carr, A.; Tsezou, A.; Gonzalez, A.; Loughlin, J.; Slagboom, E. (2011)
    Objective To study whether common genetic variants of the genes involved in the complex regulatory mechanism determining the intracellular bio-availability of T3 influence osteoarthritis onset. Methods In total 17 genetic ...
  • Meta-analysis of association between the ASPN D-repeat and osteoarthritis 

    Nakamura, T.; Shi, D.; Tzetis, M.; Rodriguez-Lopez, J.; Miyamoto, Y.; Tsezou, A.; Gonzalez, A.; Jiang, Q.; Kamatani, N.; Loughlin, J.; Ikegawa, S. (2007)
    Osteoarthritis (OA) is the most common form of human arthritis. Genetic factors have been implicated in OA. It was reported that an aspartic acid (D)-repeat polymorphism in the gene encoding asporin (ASPN) was associated ...