Now showing items 1-16 of 16

  • ASSOCIATION OF A BMP5 MICROSATELLITE WITH KNEE OSTEOARTHRITIS 

    Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)
  • Association of a BMP5 microsatellite with knee osteoarthritis: case-control study 

    Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)
    Introduction: We aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection. Methods: OA patients ...
  • Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes 

    Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)
    Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ...
  • DEEP SEQUENCING OF GDF5 IN OVER 1900 OSTEOARTHRITIS CASES AND CONTROLS REVEALS NOVEL AND POTENTIALLY FUNCTIONAL RARE VARIANTS IN THE PROTEIN CODING AND PROMOTER REGIONS OF THE GENE 

    Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Gonzalez, A.; Loughlin, J. (2010)
  • Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus 

    Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Reynard, L. N.; Gonzalez, A.; Loughlin, J. (2011)
    Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ...
  • FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors 

    Montes, A.; Perez-Pampin, E.; Joven, B.; Carreira, P.; Fernandez-Nebro, A.; Ordonez, M. D.; Navarro-Sarabia, F.; Moreira, V.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Canete, J. D.; de la Serna, A. R.; Magallares, B.; Narvaez, J.; Gomez-Reino, J. J.; Gonzalez, A. (2015)
    Objectives: Reproducible association of a functional polymorphism in FCGR2A with response to a TNF inhibitor (TNFi) in patients with rheumatoid arthritis (RA) led us to explore other Fc gamma R functional polymorphisms. ...
  • Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis 

    Rodriguez-Lopez, J.; Mustafa, Z.; Pombo-Suarez, M.; Malizos, K. N.; Rego, I.; Blanco, F. J.; Tsezou, A.; Loughlin, J.; Gomez-Reino, J. J.; Gonzalez, A. (2008)
    Objective. Given the recent characterization of ADAMTS-5 as the main aggrecanase of cartilage destruction in mouse models, we explored whether genetic variation and, in particular, putative damaging polymorphisms in the ...
  • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study 

    Panoutsopoulou, K.; Southam, L.; Elliott, K. S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N. K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W. E. R.; Ralston, S. H.; Spector, T. D.; Valdes, A. M.; Wallis, G. A.; Wilkinson, J. M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F. J.; Bumpstead, S.; Cupples, L. A.; Day-Williams, A. G.; Dixon, K.; Doherty, S. A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J. J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hunt, S. E.; Ioannidis, J. P. A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H. J. M.; Kloppenburg, M. G.; Koller, N.; Lakenberg, N.; Lane, N. E.; Lee, A. T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M. C.; O'Neill, F.; Parimi, N.; Potter, S. C.; Rego-Perez, I.; Riancho, J. A.; Sherburn, K.; Slagboom, P. E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A. G.; van Meurs, J. B. J.; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J. M.; Zeggini, E.; Loughlin, J.; arc, Ogen Consortium (2011)
    Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...
  • Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis 

    Marquez, A.; Ferreiro-Iglesias, A.; Davila-Fajardo, C. L.; Montes, A.; Pascual-Salcedo, D.; Perez-Pampin, E.; Moreno-Ramos, M. J.; Garcia-Portales, R.; Navarro, F.; Moreira, V.; Magro, C.; Caliz, R.; Ferrer, M. A.; Alegre-Sancho, J. J.; Joven, B.; Carreira, P.; Balsa, A.; Vasilopoulos, Y.; Sarafidou, T.; Cabeza-Barrera, J.; Narvaez, J.; Raya, E.; Canete, J. D.; Fernandez-Nebro, A.; Ordonez, M. D.; de la Serna, A. R.; Magallares, B.; Gomez-Reino, J. J.; Gonzalez, A.; Martin, J. (2014)
    Introduction: In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with ...
  • Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations 

    Meulenbelt, I.; Chapman, K.; Dieguez-Gonzalez, R.; Shi, D.; Tsezou, A.; Dai, J.; Malizos, K. N.; Kloppenburg, M.; Carr, A.; Nakajima, M.; van der Breggen, R.; Lakenberg, N.; Gomez-Reino, J. J.; Jiang, Q.; Ikegawa, S.; Gonzalez, A.; Loughlin, J.; Slagboom, E. P. (2009)
    Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently ...
  • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

    Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
    Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...
  • NEW FUNCTIONAL MICROSATELLITE ASSOCIATED WITH OSTEOARTHRITIS SUSCEPTIBILITY 

    Vidal-Bralo, L.; Rodriguez-Fontela, C.; Calaza, M.; Oreiro, N.; Blanco, F. J.; Carr, A.; Odriozola, A.; Riancho, J.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A.; arc, Ogen Consortium (2014)
  • New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study 

    Nakajima, M.; Takahashi, A.; Kou, I.; Rodriguez-Fontenla, C.; Gomez-Reino, J. J.; Furuichi, T.; Dai, J.; Sudo, A.; Uchida, A.; Fukui, N.; Kubo, M.; Kamatani, N.; Tsunoda, T.; Malizos, K. N.; Tsezou, A.; Gonzalez, A.; Nakamura, Y.; Ikegawa, S. (2010)
    Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through ...
  • REDUCED CLINICAL IMPROVEMENT IN RHEUMATOID ARTHRITIS PATIENTS SHOWING IGG1 ALLOTYPE -INFLIXIMAB INCOMPATIBILITY 

    Montes, A.; Perez-Pampin, E.; Navarro-Sarabia, F.; Moreira, V.; de la Serna, A. R.; Magallanes, B.; Vasilopoulos, Y.; Sarafidou, T.; Fernandez-Nebro, A.; Ordonez, M. D. C.; Narvaez, J.; Canete, J. D.; Isaacs, J.; Morgan, A.; Barton, A.; Wilson, A. G.; Gomez-Reino, J. J.; Gonzalez, A.; Bragggss (2013)
  • Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study 

    Montes, A.; Perez-Pampin, E.; Navarro-Sarabia, F.; Moreira, V.; de la Sema, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Fernandez-Nebro, A.; Ordonez, M. D.; Narvaez, J.; Canete, J. D.; Marquez, A.; Pascual-Salcedo, D.; Joven, B.; Carreira, P.; Moreno-Ramos, M. J.; Caliz, R.; Ferrer, M. A.; Garcia-Portales, R.; Blanco, F. J.; Magro, C.; Raya, E.; Valor, L.; Alegre-Sancho, J. J.; Balsa, A.; Martin, J.; Plant, D.; Isaacs, J.; Morgan, A. W.; Barton, A.; Wilson, A. G.; Gomez-Reino, J. J.; Gonzalez, A.; Braggss (2015)
    Introduction: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor ...
  • Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections 

    Dieguez-Gonzalez, R.; Calaza, M.; Shi, D.; Meulenbelt, I.; Loughlin, J.; Tsezou, A.; Dai, J.; Malizos, K. N.; Slagboom, E. P.; Kloppenburg, M.; Chapman, K.; Jiang, Q.; Kremer, D.; Gomez-Reino, J. J.; Nakajima, N.; Ikegawa, S.; Gonzalez, A. (2009)
    Objectives: To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2). Methods: Five collections ...