Now showing items 1-3 of 3

  • Inhibitor design for ribonuclease A: the binding of two 5 '-phosphate uridine analogues 

    Tsirkone, V. G.; Dossi, K.; Drakou, C.; Zographos, S. E.; Kontou, M.; Leonidas, D. D. (2009)
    In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5'-phosphate (U5P) and uridine 5'-diphosphate ...
  • Ribonucleases protect RNA from acid precipitation 

    Kouretas, D.; Antonoglou, O. (1997)
    Four, widely used, ribonucleases were found to protect their substrates from acid precipitation by causing, evidently, a modification of their physicochemical properties. The protection was dependent on the kind of substrate ...
  • Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation 

    Parmenopoulou, V.; Chatzileontiadou, D. S. M.; Manta, S.; Bougiatioti, S.; Maragozidis, P.; Gkaragkouni, D. N.; Kaffesaki, E.; Kantsadi, A. L.; Skamnaki, V. T.; Zographos, S. E.; Zounpoulakis, P.; Balatsos, N. A. A.; Komiotis, D.; Leonidas, D. D. (2012)
    Five ribofuranosyl pyrimidine nucleosides and their corresponding 1,2,3-triazole derivatives have been synthesized and characterized. Their inhibitory action to Ribonuclease A has been studied by biochemical analysis and ...